Advances in Oncolytic Virus Therapy for Glioma
نویسندگان
چکیده
منابع مشابه
Cancer Therapy: Preclinical Preferential Replication of Systemically Delivered Oncolytic Vaccinia Virus in Focally Irradiated Glioma Xenografts
Purpose:Radiotherapy is part of the standardof care inhigh-grade gliomasbut its outcomes remainpoor. Integrating oncolytic viruses with standard anticancer therapies is an area of active investigation. The aim of this study was to determine how tumor-targeted ionizing radiation (IR) could be combined with systemically delivered oncolytic vaccinia virus. Experimental Design:U-87 glioma xenograft...
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Many drugs have been developed and optimized for the treatment of cancer; however, it is difficult to completely cure cancer with anticancer drugs alone. Therefore, the development of new therapeutic technologies, in addition to new anticancer drugs, is necessary for more effective oncotherapy. Oncolytic viruses are one potential new anticancer strategy. Various oncolytic viruses have been deve...
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Oncolytic herpes simplex virus type 1 (oHSV-1) therapy is an emerging treatment modality that selectively destroys cancer. Here we report use of a glioma specific HSV-1 amplicon virus (SU4-124 HSV-1) to selectively target tumour cells. To achieve transcriptional regulation of the SU4-124 HSV-1 virus, the promoter for the essential HSV-1 gene ICP4 was replaced with a tumour specific survivin pro...
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The first gene therapy that was used on humans was performed for adenosine deaminase (ADA) deficiency in 1990 [1]. In the early days of gene therapy, it was thought to be a break‐ through in the treatment of a number of human diseases including cancer, cardiovascular disease, genetic disease, and so on. However, two severe adverse events in gene therapy served as triggers for the rethinking of ...
متن کاملChina approves world's first oncolytic virus therapy for cancer treatment.
Oncolytic virus research got a welcome boost last November when Chinese regulators approved the world’s fi rst oncolytic viral therapy for cancer, Shanghai Sunway Biotech’s genetically modifi ed adenovirus H101. “ It’s fantastic for the fi eld, ” said John Bell , Ph.D., of the Ottawa Health Research Institute in Canada. “ We needed to have something that was a success, and so I think this is a ...
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ژورنال
عنوان ژورنال: Recent Patents on CNS Drug Discovery
سال: 2009
ISSN: 1574-8898
DOI: 10.2174/157488909787002573